This formulation is a prime example of why we emphasize a coordinated, multinutrient approach whenever possible to promote maximum benefit and safety. The brain’s complex metabolism requires many different nutrients for optimum cellular communication and a balanced response to stress. Excessive or chronic release of adrenaline and cortisol, accumulated effects of environmental exposures, and oxygenation can affect the brain with an impact on mental alertness, memory, and other functions. While using one or two neuro-supportive nutrients can help target specific areas of function, care is needed to avoid potentially harmful effects of over stimulating only one neurotransmitter pathway.